Identifying factors which influence cancer risk, survival and survivorship

(PI: Dr Terry Boyle)

A cohort of 500 cancer survivors was established in 2013-14, and the first follow-up of these participants was completed in the second half of 2017. Baseline assessment involved collection of sleep quality and duration;sedentary time and physical activity (assessed with an accelerometer); clinical, demographic and lifestyle factors; patient-reported outcomes. Patient-reported outcomes and sleep data were collected again at follow up. 

Data from this cohort is being used to prospectively examine interdependent associations between sleep, sedentary and physical activity behaviours, as well as changes in patient reported outcomes (including health related quality of life, fatigue, depression, anxiety and cognitive functioning) in breast cancer, colon cancer and non-Hodgkin lymphoma survivors. 

We are also working with researchers in the Netherland, United States, Canada and Australia to pool data form eight studies to identify and investigate the correlates of daily activity patterns in cancer survivors, and investigate whether these correlates differ by cancer type. 

(PI: Dr Terry Boyle)

Using pooled data from 11 studies (from the United States, United Kingdom, Canada, Europe and Australia) in the International Lymphoma Epidemiology Consortium, we are investigating the associations between physical activity, sedentary work and the risk of non-Hodgkin lymphoma subtypes. The overall aim of the proposed project is to investigate four specific research questions:

1. Are there differential associations between physical activity and non-Hodgkin lymphoma risk between males & females?
2. Are there differential associations between physical activity and different non-Hodgkin lymphoma subtypes?
3. Does intensity influence the association between physical activity and non-Hodgkin lymphoma risk?
4. Is sedentary work associated with the risk of non-Hodgkin lymphoma?

While there is strong evidence indicating some modifiable exposures (such as physical activity, diet, and obesity) influence cancer risk, all studies to date have been observational as it isn't feasible to conduct randomised trials on these exposures. A different approach to investigate cancer risk factors is by using Mendelian Randomisation. New research indicates some genes are associated with modifiable exposures. Mendelian Randomisation uses individual variation in these genes as a proxy for a particular modifiable exposure to make a causal inference about the relationship between that modifiable exposure and cancer risk. We use information from the UK Biobank and other large scale studies to investigate the causal associations between specific modifiable exposures and the risk of cancer.