NHMRC Grant: Persistent firing in cortical interneurons: mechanisms and potential anticonvulsant rol

A collaboration with John Curtin School of Medical Research, Australian National University


The aim of this project is to test the idea that certain classes of cortical inhibitory interneurons are adapted for a specialised anticonvulsant role in the mammalian cerebral cortex, because they possess a recently-discovered property called persistent firing. The project will investigate the cellular mechanisms that give rise to persistent firing, as well as study the potential role of this phenomenon in suppressing seizures in a mouse model of epilepsy.

Project Type

Research Grant

Prof John Bekkers and A/Prof Mark McDonnell

2013 - 2015